Published intermittently. Always cultural, never prescriptive. Subscribe to the monthly letter to get the next one in your inbox.
The cultural shorthand started in late 2024. Patients report blunted cravings — for food, alcohol, shopping, gambling, even Instagram. The mechanism is real: GLP-1 receptors are densely expressed in reward circuits. Here is the honest cultural read on what is signal and what is anecdote.
Read the essay →Everyone repeats 24%. I think it is the least interesting figure in the Phase 2 data — and the five that matter are what the TRIUMPH readouts will decide.
Essay · NewFor a century the equation had two terms: diet and exercise. Then a generation woke up and the sentence had a third. An essay on what that third sentence does to a culture.
Cultural · EssayThe cultural phenomenon, the honest read on the neuroscience, and what it means for how we talk about pleasure and motivation in the medicated era.
ReportageWhat it means culturally that the next generation of weight-loss medication is a tablet. How the conversation shifts when the friction of injection disappears.
ReportageEvery wave of medication brings its own cultural ripples. A reportage on what is coming, what it means for the conversation, and the questions the data cannot answer.
Reportage · PolicyIn February 2026, HHS moved 14 previously restricted molecules back toward legal compounding access. The cultural and political backdrop of a quiet rule change.